Background:

This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).

Applications:

ELISA, IHC

Name of antibody:

FYCO1

Immunogen:

Fusion protein of human FYCO1

Full name:

FYVE and coiled-coil domain containing 1

Synonyms:

CATC2; RUFY3; ZFYVE7; CTRCT18

SwissProt:

Q9BQS8

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human cervical cancer

IHC Recommend dilution:

100-200