Background:

VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.

Applications:

ELISA, IHC

Name of antibody:

VWA5A

Immunogen:

Fusion protein of human VWA5A

Full name:

von Willebrand factor A domain containing 5A

Synonyms：

BCSC1; BCSC-1; LOH11CR2A

SwissProt:

O00534

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human cervical cancer and human lung cancer

IHC Recommend dilution:

100-300