Background:

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

RUNX1(Phospho-Ser303)

Immunogen:

Peptide sequence around phosphorylation site of serine 303 (T-A-F(p)-S-D) derived from Human AML1.

Full name:

runt-related transcription factor 1

Synonyms：

AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1

SwissProt:

Q01196

WB Predicted band size:

49 kDa

WB Positive control:

Jurkat cells lysates

WB Recommended dilution:

500-1000