Background:

This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease.

Applications:

ELISA, IHC

Name of antibody:

PPP1R3C

Immunogen:

Fusion protein of human PPP1R3C

Full name:

protein phosphatase 1 regulatory subunit 3C

Synonyms:

PTG; PPP1R5

SwissProt:

Q9UQK1

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human esophagus cancer

IHC Recommend dilution:

50-300