Background:

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

Applications:

WB, IHC

Name of antibody:

TFAP2A

Immunogen:

Synthesized peptide derived from human AP-2.

Full name:

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Synonyms：

AP-2; BOFS; AP2TF; TFAP2; AP-2alpha

SwissProt:

P05549

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

48 kDa

WB Positive control:

COLO205 cells lysate

WB Recommended dilution:

500-3000