Background:

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Applications:

ELISA, IHC

Name of antibody:

PDCD1

Immunogen:

Synthetic peptide of human PDCD1

Full name:

Programmed cell death 1

Synonyms:

PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l

SwissProt:

Q15116

IHC positive control:

Human gastric cancer and human lung cancer

IHC Recommend dilution:

50-200